Early manifestation of myocardial involvement in systemic sclerosis

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Primary myocardial involvement in systemic sclerosis.

Systemic sclerosis (SSc) is a connective tissue disease characterized by diffuse vascular lesions and fibrosis. Primary myocardial involvement is common in SSc and, when clinically evident, appears as a poor prognostic factor. An increasing body of evidence suggests that myocardial involvement is due, at least in part, to microcirculation impairment with abnormal vasoreactivity, with or without...

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Association between atherosclerosis and parenchymal lung involvement in systemic sclerosis

Background: Systemic sclerosis is an autoimmune disease affecting connective tissues, (including epidermal, subepidermal, microvasculature, etc.), leading to various extent of end-organ damage. The leading cause of mortality among these patients is lung involvement. The cardiovascular events happen more frequently in patients suffering systemic scleroderma, comparing to healthy population. This...

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Articular involvement in systemic sclerosis.

Articular involvement is frequent in SSc. It contributes to disability and compromises patients' quality of life. Different aspects of articular involvement have been described, ranging from arthralgia and arthritis to joint contracture and tendon sheath involvement. Recent cohort studies examining clinical and radiographic aspects of SSc have clarified the frequency of articular involvement an...

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Pericardial involvement in systemic sclerosis.

OBJECTIVE To determine the frequency and histological characteristics of pericardial involvement in systemic sclerosis. METHOD Necropsy sections of pericardium from 44 patients with systemic sclerosis were studied, together with sections from 19 age/sex matched controls. Sections were stained with haematoxylin and eosin, acid toluidine blue, and elastic van Gieson. Mast cells were counted in ...

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Musculoskeletal Involvement in Systemic Sclerosis

Joint involvement in SSc affects 46-97% of patients with SSc [3]. Generalized inflammatory arthralgias with pain and stiffness are the usual presentation of articular involvement. All joints may be affected, mainly the fingers (in particular the Metacarpophalangeal (MCP) and Proximal Interphalangeal (PIP) joints), wrists and ankles. Franck arthritis is less common. The onset of this latter may ...

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ژورنال

عنوان ژورنال: Revista Portuguesa de Cardiologia

سال: 2019

ISSN: 0870-2551

DOI: 10.1016/j.repc.2017.07.022